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The nuclear lamina consists of two components, lamins and nuclear lamin-associated membrane proteins. The lamins are type V intermediate filaments which can be categorized as either A-type (lamin A, C) or B-type (lamin B 1, B 2) according to homology of their DNA sequences, biochemical properties and cellular localization during the cell cycle.
6839 20937 Ensembl ENSG00000101945 ENSMUSG00000039231 UniProt O43463 O54864 RefSeq (mRNA) NM_003173 NM_001282166 NM_001290716 NM_011514 NM_001358237 RefSeq (protein) NP_001269095 NP_003164 NP_001277645 NP_035644 NP_001345166 Location (UCSC) Chr X: 48.7 – 48.71 Mb Chr X: 7.93 – 7.94 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Histone-lysine N-methyltransferase SUV39H1 is an ...
The organization of chromosomes into distinct regions within the nucleus was first proposed in 1885 by Carl Rabl.Later in 1909, with the help of the microscopy technology at the time, Theodor Boveri coined the termed chromosome territories after observing that chromosomes occupy individually distinct nuclear regions. [6]
The isoforms 1 and 3 of human NPM1 are B23.1 and B23.2 respectively in rat. [7] The isoform 1 is localized to the nucleolus [ 8 ] as is reported for rat B23.1 [ 9 ] [ 10 ] whereas the isoform 3 (B23.2) is nucleoplasmic or cytoplasmic in localization and is expressed at relatively lower levels as compared to isoform 1 in normal rat tissues [ 11 ...
The inner nuclear membrane encloses the nucleoplasm, and is covered by the nuclear lamina, a mesh of intermediate filaments which stabilizes the nuclear membrane as well as being involved in chromatin function. [9] It is connected to the outer membrane by nuclear pores which penetrate the membranes.
The presence of intra-cellular proteins is common ground, and it is agreed that proteins such as the Scaffold, or Matrix Associated Proteins (SAR or MAR) have some role in the organisation of chromatin in the living cell. There is evidence that the nuclear matrix is involved in regulation of gene expression in Arabidopsis thaliana.
Nucleoplasm is quite similar to the cytoplasm, with the main difference being that nucleoplasm is found inside the nucleus while the cytoplasm is located inside the cell, outside of the nucleus. Their ionic compositions are nearly identical due to the ion pumps and permeability of the nuclear envelope, however, the proteins in these two fluids ...
It has been proposed that chromatin-binding/modifying proteins embedded within the inner nuclear membrane may be central in determining the identity of newly differentiated cells. The nucleoplasmic domains of such proteins can interact with chromatin to create a scaffold and restrict the conformation of chromosomes within three dimensions.