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Conditions where this is found include aplastic, posthemorrhagic, and hemolytic anemias and anemia of chronic disease. [ 1 ] MCH (average amount of hemoglobin found in the red blood cells in the body) or MCHC (the average weight of that hemoglobin based on the volume of red blood cells) in these cells are normal.
Serum iron and ferritin: these tests are needed to rule out iron-deficiency anemia. [42] For an exact diagnosis, the following tests can be performed: Hemoglobin electrophoresis is a test that can detect different types of hemoglobin. Hemoglobin is extracted from the red cells, then introduced into a porous gel and subjected to an electrical field.
Pernicious anemia was a fatal disease before about the year 1920; until the importance of the liver in hematopoiesis was recognized, the treatment of pernicious anemia was unsuccessful and arbitrary. It may have motivated George Whipple , who had a keen interest in liver diseases , to investigate the liver's role in hematopoiesis.