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In September 2003, Howitz and Sinclair et al. published a highly cited paper reporting that polyphenols such as resveratrol [2] activate human SIRT1 and extend the lifespan of budding yeast (Howitz et al., Nature, 2003). Other examples of such products are butein, piceatannol, isoliquiritigenin, fisetin, and quercetin.
David Andrew Sinclair AO (born June 26, 1969) is an Australian-American biologist and academic known for his research on aging and epigenetics.Sinclair is a professor of genetics at Harvard Medical School and the founding director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard.
[53] [57] [58] [59] In 2004, Harvard University professor David Sinclair co-founded Sirtris Pharmaceuticals, the initial product of which was a resveratrol formulation. [ 60 ] [ 61 ] [ 62 ] Sirtris was purchased and made a subsidiary of GlaxoSmithKline in 2008 for $720 million and shut down in 2013, without successful drug development.
A review for Boston Magazine called Sinclair "one of science's most controversial figures" and said many in the scientific community were skeptical of claims he made about human longevity. University of Alabama biology professor Steven N. Austad said, "David is a good friend, but I do think he's been guilty of making excessive claims."
David Sinclair and Rachel Drake shattered records in winning the men's and women's titles in the 62nd annual JFK 50 Mile ultramarathon on Saturday. Sinclair, 32, of South Burlington, Vermont, took ...
Sirtris Pharmaceuticals, Inc. was a biotechnology company based in Cambridge, MA that developed therapies for type 2 diabetes, cancer, and other diseases. Conceived in 2004 by Harvard University biologist David Sinclair and Andrew Perlman, [1] and founded that year by Sinclair and Perlman, along with Christoph Westphal, Richard Aldrich, Richard Pops, and Paul Schimmel, [2] the company was ...
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Fisetin (7,3′,4′-flavon-3-ol) is a plant flavonol from the flavonoid group of polyphenols. [1] It can be found in many plants, where it serves as a yellow/ ochre colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions and cucumbers. [ 2 ]