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Methylene blue has been described as "the first fully synthetic drug used in medicine." Methylene blue was first prepared in 1876 by German chemist Heinrich Caro. [69] Its use in the treatment of malaria was pioneered by Paul Guttmann and Paul Ehrlich in 1891. During this period before the first World War, researchers like Ehrlich believed that ...
Wright's stain is a hematologic stain that facilitates the differentiation of blood cell types. It is classically a mixture of eosin (red) and methylene blue dyes. It is used primarily to stain peripheral blood smears, urine samples, and bone marrow aspirates, which are examined under a light microscope.
Notably, methylene blue is used as as the main treatment for methemoglobinemia, however in G6PD individuals, methylene blue may cause further oxidative stress and that may induce or worsen hemolysis in those with methemoglobinemia [1]. Hemolytic anemia may also occur secondarily due to thrombotic microangiopathy after
e.g. Methylene blue, Safranin°≤×←→ etc. Used to highlight microbes and illustrate cellular shapes and arrangements Organisms are stained in the color of applied stain 2. Negative (Relief) Smear mixed with Nigrosin and spread into thin film Study cell morphology Organism is stained, the background is black 3 Gram
Genetically induced chronic low-level methemoglobinemia may be treated with oral methylene blue daily. Also, vitamin C can occasionally reduce cyanosis associated with chronic methemoglobinemia, and may be helpful in settings in which methylene blue is unavailable or contraindicated (e.g., in an individual with G6PD deficiency). [22]
For this test, the patient takes oral phenazopyridine (Pyridium) 200 mg three times a day, and indigo carmine or methylene blue is filled into the empty urinary bladder via a urethral catheter. Pyridium turns urine orange in the kidneys, and methylene blue (or indigo carmine) turns urine blue in the bladder. [1] A tampon is placed into the ...
The Wayson stain is a basic fuchsin-methylene blue, ethyl alcohol-phenol microscopic staining procedure. It was originally a modified methylene blue stain used for diagnosing bubonic plague. [1] With this stain, Yersinia pestis appears purple with a characteristic safety-pin appearance, [2] which is due to the presence of a central vacuole.
Methyl blue is a chemical compound with the molecular formula C 37 H 27 N 3 Na 2 O 9 S 3.It is used as a stain in histology, [1] and stains collagen blue in tissue sections. It can be used in some differential staining techniques such as Mallory's connective tissue stain and Gömöri trichrome stain, and can be used to mediate electron transfer in microbial fuel cells.
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