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The initial recommended treatment depends on the type of hepatitis C virus, if the person has received previous hepatitis C treatment, and whether the person has cirrhosis. [88] Direct-acting antivirals are the preferred treatment and have been validated by testing for virus particles in patients' blood. [89]
In the European Union it was approved in July 2016, for the treatment of chronic hepatitis C virus infection in adults. [7] The safety and efficacy of sofosbuvir/velpatasvir for a 12-week treatment was evaluated in three Phase III clinical trials of 1,558 subjects without cirrhosis or with compensated cirrhosis (mild cirrhosis). [13]
Ledipasvir/sofosbuvir, sold under the trade name Harvoni among others, is a medication used to treat hepatitis C. [8] It is a fixed-dose combination of ledipasvir and sofosbuvir. [8] Cure rates are 94% to 99% in people infected with hepatitis C virus (HCV) genotype 1. [9] Some evidence also supports use in HCV genotype 3 and 4. [9]
Hepatitis C is an infection of the liver caused by the hepatitis C virus (HCV). ... Certain medications are recommended more for certain genotypes (and subgenotypes) of hepatitis C than for others ...
For the other, roughly 70 percent of people with hepatitis C, the body’s immune system cannot boot the virus out so easily, and eventually, the infection becomes ongoing, or chronic, lasting for ...
Sofosbuvir is also used with other medications and longer treatment durations, depending on specific circumstances, genotype and cost-effectiveness–based perspective. For example, for the treatment of genotypes 1, 4, 5, and 6 hepatitis C infections, sofosbuvir can be used in combination with the viral NS5A inhibitor ledipasvir. [16]
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