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Sofosbuvir/velpatasvir, sold under the brand name Epclusa among others, is a fixed-dose combination medication for the treatment of hepatitis C in adults. [2] [5] [6] [7] It combines sofosbuvir and velpatasvir. [2] [5] [6] It is more than 90% effective for hepatitis C genotypes one through six. [2]
Sofosbuvir, sold under the brand name Sovaldi among others, is a medication used to treat hepatitis C. [3] It is taken by mouth. [3] [6]Common side effects include fatigue, headache, nausea, and trouble sleeping. [3]
Glecaprevir (INN, [1]) is a hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease inhibitor that was identified jointly by AbbVie and Enanta Pharmaceuticals. [2] It is being developed as a treatment of chronic hepatitis C infection in co-formulation with an HCV NS5A inhibitor pibrentasvir.
[5] [6] It works against all six types of hepatitis C. [4] At twelve weeks following treatment between 81% and 100% of people have no evidence of hepatitis C. [7] It is taken once a day by mouth with food. [4] [5] The most common side effects are headache, diarrhea, and tiredness. [7] [8] In those with a history of hepatitis B, reactivation may ...
Ledipasvir/sofosbuvir, sold under the trade name Harvoni among others, is a medication used to treat hepatitis C. [8] It is a fixed-dose combination of ledipasvir and sofosbuvir. [8] Cure rates are 94% to 99% in people infected with hepatitis C virus (HCV) genotype 1. [9] Some evidence also supports use in HCV genotype 3 and 4. [9]
In 2014, an estimated 30,500 new acute hepatitis C cases occurred (0.7 per 100,000 population), an increase from 2010 to 2012. [120] The number of deaths from hepatitis C rose to 15,800 in 2008 [121] having overtaken HIV/AIDS as a cause of death in the US in 2007. [122]
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