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Cerebrospinal fluid (CSF) is a clear, colorless transcellular body fluid found within the meningeal tissue that surrounds the vertebrate brain and spinal cord, and in the ventricles of the brain. CSF is mostly produced by specialized ependymal cells in the choroid plexuses of the ventricles of the brain, and absorbed in the arachnoid ...
An increase in pressure, most commonly due to head injury leading to intracranial hematoma or cerebral edema, can crush brain tissue, shift brain structures, contribute to hydrocephalus, cause brain herniation, and restrict blood supply to the brain. [13] It is a cause of reflex bradycardia. [14]
Lymphocytic pleocytosis is an abnormal increase in the amount of lymphocytes in the cerebrospinal fluid (CSF). It is usually considered to be a sign of infection or inflammation within the nervous system , and is encountered in a number of neurological diseases , such as pseudomigraine, Susac's syndrome, and encephalitis.
A spinal CSF leak can be caused by one or more meningeal diverticula or CSF-venous fistulas not associated with an epidural leak. [6] [7] [8] A spontaneous spinal cerebrospinal fluid leak may occur sometimes in those with predisposing heritable connective tissue disorders including Marfan syndrome and Ehlers–Danlos syndromes.
“When you’re in a deep sleep, it allows spinal fluid to come in and flush out debris, including beta-amyloid plaques, which can be a significant risk factor for Alzheimer’s disease,” says ...
Similarly, interstitial fluid is cleared from the brain parenchyma via the paravascular spaces surrounding large draining veins. [ citation needed ] Paravascular spaces are CSF-filled channels formed between the brain blood vessels and leptomeningeal sheathes that surround cerebral surface vessels and proximal penetrating vessels.
The Valsalva maneuver may help check for a dural tear following certain spinal operations, such as a microdiscectomy. An increase in intra-spinal pressure will cause cerebral spinal fluid (CSF) to leak out of the dura, causing a headache. [citation needed] The Valsalva maneuver has been associated with transient global amnesia. [17] [18] [19 ...
The breakdown of the tight endothelial junctions that make up the blood–brain barrier causes extravasation of fluid, ions, and plasma proteins, such as albumin, into the brain parenchyma. [18] Accumulation of extracellular fluid increases brain volume and then intracranial pressure causing the symptoms of cerebral edema. [1]