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The protoplasmic material of the nucleus including the nucleolus labelled as nucleoplasm. The nucleoplasm, also known as karyoplasm, [1] is the type of protoplasm that makes up the cell nucleus, the most prominent organelle of the eukaryotic cell. It is enclosed by the nuclear envelope, also known as the nuclear membrane. [2]
Chromatin is a complex of DNA and protein found in eukaryotic cells. [1] The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important roles in reinforcing the DNA during cell division , preventing DNA damage , and regulating gene expression ...
The cell nucleus (from Latin nucleus or nuculeus 'kernel, seed'; pl.: nuclei) is a membrane-bound organelle found in eukaryotic cells.Eukaryotic cells usually have a single nucleus, but a few cell types, such as mammalian red blood cells, have no nuclei, and a few others including osteoclasts have many.
Thus, the entire chromosome, i.e. chromatin in eukaryotes consists of such nucleoproteins. [2] [13] In eukaryotic cells, DNA is associated with about an equal mass of histone proteins in a highly condensed nucleoprotein complex called chromatin. [14]
The heterotrimeric chaperone chromatin assembly factor 1 is a chromatin formation protein that is involved in depositing histones onto both newly replicated DNA strands to form chromatin. [145] CAF-1 contains a PCNA-binding motif, called a PIP-box, that allows CAF-1 to associate with the replisome through PCNA and is able to deposit histone H3 ...
The eukaryotic genome is organized into a compact chromatin structure that allows only regulated access to DNA. The chromatin structure can be globally "open" and more transcriptionally permissive, or globally "condensed" and transcriptionally inactive. The former (euchromatin) is lightly packed and rich in genes under active transcription.
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The nuclear pore complex (NPC) is a crucial cellular structure with a diameter of approximately 120 nanometers in vertebrates. Its channel varies from 5.2 nanometers in humans [13] to 10.7 nm in the frog Xenopus laevis, with a depth of roughly 45 nm. [14]