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Low-dose spironolactone is generally very well tolerated. [62] Even higher doses of spironolactone, such as 100 mg/day, are well tolerated in most individuals. [ 62 ] Dose-dependent side effects of spironolactone include menstrual irregularities, breast tenderness, and enlargement, orthostatic hypotension , and hyperkalemia. [ 62 ]
Spironolactone has been found to be effective in the treatment of hirsutism in women at a dosage of as low as 50 mg/day. [60] At dosages of 100 mg/day and 200 mg/day, observed reductions in hair shaft diameter were 19% ± 8% and 30% ± 3%, respectively ( p = 0.07).
Triamterene – increased renal side-effects; Aldosterone antagonists, also known as mineralocorticoid receptor antagonists: [7] Spironolactone – most widespread use, inexpensive; Eplerenone – more selective so reduced side-effects but more expensive and less potent
Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]
Spironolactone: Spironolactone is used to treat high blood pressure but is also prescribed off-label for treating acne in women. Spironolactone reduces the amount of androgen hormones in your body ...
Prescription oral medications: Oral meds are often a first-line treatment, with low-dose oral minoxidil (which is used off-label) being the most popular. “It offers an improved result for many ...
In the low-dose short test, 1 μg of an ACTH drug is injected into the patient. In the conventional-dose short test, 250 μg of drug are injected. Both of these short tests last for about an hour and provide the same information. Studies have shown the cortisol response of the adrenals is the same for the low-dose and conventional-dose tests ...
Red light therapy for hair growth is FDA-approved and comes with very few side effects; and has been found in clinical studies to help encourage hair growth over time with regular use — every ...