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The IRB must ensure that the assent process is appropriate for children. A child cannot legally give informed consent but they must be given the opportunity to decline. A parent or guardian legally consents to the child's participation. Additional safeguards exist for "wards of the state" such as orphans.
As children often lack the decision-making ability or legal power (competence) to provide true informed consent for medical decisions, it often falls on parents or legal guardians to provide informed permission for medical decisions. This "consent by proxy" usually works reasonably well, but can lead to ethical dilemmas when the judgment of the ...
A child over 7 years old who declines treatment for a devastating childhood illness and is therefore in mortal danger, might have their dissent overridden and have treatment forced upon them. [12] A child over 14 years old may be able to provide their own informed consent, independent of their parents. [13]
The informed consent of one legal guardian is required to recruit children for clinical trials. [18] In some cases, parents do not understand randomization, do not know they can withdraw their child from the study, do not know they can decline participation in a study, or want their physician to make the decision to participate. [ 19 ]
Typical exclusion criteria are defined for either ethical reasons (e.g., children, pregnant women, patients with psychological illnesses, patients who are not able or willing to sign informed consent), to overcome practical issues related to the study itself (e.g., not being able to read, when questionnaires are used for assessment of outcomes ...
A traditional snickerdoodle recipe includes unsalted butter, granulated sugar, eggs, all-purpose flour, cream of tartar, baking soda and salt.
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