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Sulfasalazine metabolizes to sulfapyridine. Serum levels should be monitored every three months, and more frequently at the outset. Serum levels above 50 μg/L are associated with side effects. In rare cases, sulfasalazine can cause severe depression in young males. It can also cause oligospermia and temporary infertility.
Sulfapyridine levels above 50 μg/L are associated with the side-effects. Patients on high dose sulfasalazine require folic supplementation (1 mg/day) (1000 μg/day) to maintain normal cell division. This may, however, be counter-productive for patients who are also taking methotrexate, which is a folic acid inhibitor.
Long term [1] Causes: Unknown [1] Diagnostic method: Colonoscopy with tissue biopsies [1] Differential diagnosis: Dysentery, Crohn's disease, ischemic colitis [4] Treatment: Dietary changes, medication, surgery [1] Medication: Sulfasalazine, mesalazine, steroids, immunosuppressants such as azathioprine, biological therapy [1] Frequency: 2–299 ...
Common side effects include nausea, diarrhea, headache, fever, rash, depression, and pancreatitis. [1] It should not be used in people who have severe liver problems, kidney problems, or porphyria. [3] If used during pregnancy, it may increase the risk of kernicterus in the baby. [1]
Common side effects include itching and pain at the site of use. [4] Other side effects include low white blood cell levels, allergic reactions, bluish grey discoloration of the skin, red blood cell breakdown, or liver inflammation. [4] Caution should be used in those allergic to other sulfonamides. [4]
Some severe side effects with long-term consequences may include pancreatitis, acute kidney injury, gallstones, gallbladder disease, diabetic retinopathy, and an increased heart rate. Semaglutide ...
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How long will the side effects from the shot most likely last? ... so this eliminates the concern of any long-term side effects. “Most side effects last 24–48 hours,” says Dr. O’Donnell ...