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Examples include clopidogrel, prasugrel and ticagrelor. Clopidogrel has a common drug interaction with CYP2C19 inhibitors, particularly omeprazole and esomeprazole which are indicated for treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Drugs in this class include: clopidogrel (Plavix), [2] prasugrel (Effient), [3] and ticlopidine (Ticlid). Tinoridine was actually a predecessor to this work. Alternatives
Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. [10] It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent ( dual antiplatelet therapy ). [ 10 ]
Some drug classes have been amalgamated from these three principles to meet practical needs. The class of nonsteroidal anti-inflammatory drugs (NSAIDs) is one such example. Strictly speaking, and also historically, the wider class of anti-inflammatory drugs also comprises steroidal anti-inflammatory drugs. These drugs were in fact the ...
The first drug introduced in this class was ticlopidine but due to adverse effects it is not much used today. Ticlopidine, clopidogrel and prasugrel (Efient) are all thienopyridines that cause irreversible inhibition of P2Y 12 receptor. They are all prodrugs which need to be converted to an active metabolite in-vivo to inhibit the P2Y 12 receptor.
Non-steroidal anti-inflammatory drugs [1] [3] (NSAID) [1] are members of a therapeutic drug class which reduces pain, [4] decreases inflammation, decreases fever, [1] and prevents blood clots. Side effects depend on the specific drug, its dose and duration of use, but largely include an increased risk of gastrointestinal ulcers and bleeds ...
The profens are a class of nonsteroidal anti-inflammatory drugs. [1] Profens are also known as 2-arylpropionic acids to reflect their chemical structure. [2] The most common example of a profen is ibuprofen, which has been sold under the brand name Profen among others. Other drugs in the class include: Alminoprofen; Benoxaprofen; Carprofen ...
Medical conditions that may increase antiplatelet drugs' effect include: [3] Chronic kidney failure , liver disease , haematological malignancy, recent or current chemotherapy , advanced heart failure, mild forms of inherited bleeding disorders (e.g. haemophilia , Von Willebrand's disease ) and idiopathic thrombocytopenic purpura .
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