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Low levels of vitamin D3 are more commonly found in individuals living in northern latitudes or with other reasons for a lack of regular sun exposure, including being housebound, frail, elderly, or obese, having darker skin, and wearing clothes that cover most of the skin. [23] [24] Supplements are recommended for these groups of people. [24]
Vitamin D deficiency remains the main cause of rickets among young infants in most countries because breast milk is low in vitamin D, and darker skin, social customs, and climatic conditions can contribute to inadequate sun exposure.
Gestational vitamin D deficiency in rats is associated with reduced levels of neurotrophic factors NGF and GDNF. [7] NGF is the nerve growth factor , which is involved in neurotransmission . GDNF is the glial cell lined derived neurotrophic factor, which is involved in the survival and differentiation of dopaminergic neurons.
Vitamin D2 vs. D3 Uses. Both vitamin D2 and vitamin D3 will help to increase vitamin D levels in the blood, says Pelitera. However, some studies have shown that supplementing vitamin D3 does a ...
Vitamin D3, aka cholecalciferol, is important for bone health and immune function. Experts discuss benefits, sources, risks and who needs a supplement.
But “vitamin D3 is more bioavailable (a.k.a has a stronger ability to be absorbed and used in the body), which is why people tend to prefer vitamin D3," says JoAnn Manson, M.D., MPH, DrPH, a ...
Calcitriol is a hormone and the active form of vitamin D, normally made in the kidney. [8] [9] [10] It is also known as 1,25-dihydroxycholecalciferol.It binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. [11]
Mapping of several bone diseases onto levels of vitamin D (calcidiol) in the blood [6] Normal bone vs. osteoporosis. Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body.
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