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The bullae are formed by an immune reaction, initiated by the formation of IgG [citation needed] autoantibodies targeting dystonin, also called bullous pemphigoid antigen 1, [6] and/or type XVII collagen, also called bullous pemphigoid antigen 2, [7] which is a component of hemidesmosomes. A different form of dystonin is associated with ...
Antibody isotype(s) and location of antibody deposition in immunofluorescence studies using salt-split skin for autoimmune bullous conditions targeting the basement membrane zone of the human integumentary system Condition Antibody isotype(s) deposited Localization of antibody with use of salt-split skin Antiepilegrin cicatricial pemphigoid ...
Bullous pemphigoid: Skin ... 1-8 per million [70] ... Anti-red blood cell antibodies Confirmed 1-3 per 100,000 [89] Immune thrombocytopenia:
This is the most specific diagnostic test for pemphigus erythematosus. [5] Indirect immunofluorescence studies can also be used to view the presence of pemphigus antibodies, however, this test involves taking a sample of the patient's blood and testing it on animal tissue (eg. monkey esophagus) and does not require a biopsy. [1]
Pemphigoid is a group of rare autoimmune blistering diseases of the skin and mucous membranes.As its name indicates, pemphigoid is similar in general appearance to pemphigus, [1] however unlike pemphigus, pemphigoid does not feature acantholysis, a loss of connections between skin cells.
The number of target antigens varies on a case by case basis. The variability is likely what accounts for the different presentations of PNP. Through immunoprecipitation, target antigens have been found to include desmoglein-3, desmoglein-1, envoplakin, periplakin, desmoplakin 1, desmoplakin 2, and bullous pemphigoid antigen I. [citation needed]
Pemphigoid variant Antibody isotype Antigen Molecular weight Bullous pemphigoid: IgG, IgE [1] NC16A terminal of BPAG2 BPAG1: 180 230 Gestational pemphigoid: IgG1: NC16A terminal of BPAG2 BPAG1: 180 230 Cicatricial pemphigoid: C-terminal of BPAG2: 180 Ocular cicatricial pemphigoid: Integrin beta-4 subunit: 200 Antiepiligrin cicatricial ...
Pemphigus, from 1886 medical book Microscopic image of direct immunofluorescence using an anti-IgG antibody. The tissue is skin from a patient with Pemphigus vulgaris.Note the intercellular IgG deposits in the epidermis and the early intraepidermal vesicle caused by acantholysis.