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In MATLAB, use myBinomTest, which is available via Mathworks' community File Exchange website. myBinomTest will directly calculate the p-value for the observations given the hypothesized probability of a success. [pout]= myBinomTest (51, 235, 1 / 6) (generally two-tailed, but can optionally perform a one-tailed test). In Stata, use bitest.
In null-hypothesis significance testing, the p-value [note 1] is the probability of obtaining test results at least as extreme as the result actually observed, under the assumption that the null hypothesis is correct. [2] [3] A very small p-value means that such an extreme observed outcome would be very unlikely under the null hypothesis.
To determine whether a result is statistically significant, a researcher calculates a p-value, which is the probability of observing an effect of the same magnitude or more extreme given that the null hypothesis is true. [5] [12] The null hypothesis is rejected if the p-value is less than (or equal to) a predetermined level, .
The positive predictive value (PPV), or precision, is defined as = + = where a "true positive" is the event that the test makes a positive prediction, and the subject has a positive result under the gold standard, and a "false positive" is the event that the test makes a positive prediction, and the subject has a negative result under the gold standard.
Under Fisher's method, two small p-values P 1 and P 2 combine to form a smaller p-value.The darkest boundary defines the region where the meta-analysis p-value is below 0.05.. For example, if both p-values are around 0.10, or if one is around 0.04 and one is around 0.25, the meta-analysis p-value is around 0
The chi-squared statistic can then be used to calculate a p-value by comparing the value of the statistic to a chi-squared distribution. The number of degrees of freedom is equal to the number of cells , minus the reduction in degrees of freedom, . The chi-squared statistic can be also calculated as
The p-values of the rejected null hypothesis (i.e. declared discoveries) are colored in red. Note that there are rejected p-values which are above the rejection line (in blue) since all null hypothesis of p-values which are ranked before the p-value of the last intersection are rejected. The approximations MFDR = 0.02625 and AFDR = 0.00730, here.
The procedures of Bonferroni and Holm control the FWER under any dependence structure of the p-values (or equivalently the individual test statistics).Essentially, this is achieved by accommodating a `worst-case' dependence structure (which is close to independence for most practical purposes).