Search results
Results from the WOW.Com Content Network
The Hofmann rearrangement (Hofmann degradation) is the organic reaction of a primary amide to a primary amine with one less carbon atom. [ 1 ] [ 2 ] [ 3 ] The reaction involves oxidation of the nitrogen followed by rearrangement of the carbonyl and nitrogen to give an isocyanate intermediate.
The Cope elimination is very similar to the Hofmann elimination in principle, but occurs under milder conditions. It also favors the formation of the Hofmann product, and for the same reasons. [3] An example of a Hofmann elimination (not involving a contrast between a Zaitsev product and a Hofmann product) is the synthesis of trans-cyclooctene. [4]
It is accompanied by carbocationic rearrangement reactions; Scheme 2. E1 reaction mechanism. An example in scheme 2 is the reaction of tert-butylbromide with potassium ethoxide in ethanol. E1 eliminations happen with highly substituted alkyl halides for two main reasons.
The resulting sodium salt of phthalamic acid is decarbonylated via a Hofmann rearrangement of the amide group, induced by hypochlorite: [15] C 6 H 4 (C(O)NH 2)CO 2 Na + HOCl → C 6 H 4 NH 2 CO 2 H + NaCl + CO 2. A related method involves treating phthalimide with sodium hypobromite in aqueous sodium hydroxide, followed by neutralization. [16]
The Hofmann–Martius rearrangement in organic chemistry is a rearrangement reaction converting an N-alkylated aniline to the corresponding ortho and / or para aryl-alkylated aniline. The reaction requires heat, and the catalyst is an acid like hydrochloric acid .
Well-dressed children watch toys in the shop window of a department store displaying Christmas decorations on December 11, 1946. AFP - Getty Images F.W. Woolworth Company: 1947
The litter returns to the main basin free of any waste, which falls into a removable bucket beneath the litter box. ... What to know about Social Security's full retirement age in 2025. Food. Food ...
Health officials in California are alerting consumers of a voluntary recall of a batch of cream top, whole milk that was produced by Raw Farms, LLC, in Fresno County after bird flu was detected in ...