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Estradiol is also produced in the brain and in arterial walls. In men, approximately 15 to 25% of circulating estradiol is produced in the testicles. [52] [53] The rest is synthesized via peripheral aromatization of testosterone into estradiol and of androstenedione into estrone (which is then transformed into estradiol via peripheral 17β-HSD).
Aromatases are enzymes that aromatize rings within steroids. The specific conversions are testosterone to estradiol and androstenedione to estrone. [5] Each of these aromatizations involves the oxidation of the C-19 methyl group to allow for the elimination of formic acid concomitant with aromatization.
Testosterone is the primary male sex hormone and androgen in males. [3] In humans, testosterone plays a key role in the development of male reproductive tissues such as testicles and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair.
Aromatase (EC 1.14.14.14), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is CYP19A1 , a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis .
Research on women and testosterone has been limited, but as more is done, experts are seeing that the hormone affects the female sex drive, just as it does the male. It also plays an essential ...
This is an accepted version of this page This is the latest accepted revision, reviewed on 25 November 2024. Polycyclic organic compound having sterane as a core structure This article is about the family of polycyclic compounds. For the drugs, also used as performance-enhancing substances, see Anabolic steroid. For the scientific journal, see Steroids (journal). For the Death Grips EP, see ...
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