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Nortriptyline is an active metabolite of amitriptyline by demethylation in the liver. Chemically, it is a secondary amine dibenzocycloheptene and pharmacologically it is classed as a first-generation antidepressant. [36] Nortriptyline may also have a sleep-improving effect due to antagonism of the H 1 and 5-HT 2A receptors. [37]
On the other hand, cytochrome P450 inducers such as carbamazepine and St. John's Wort decrease the levels of both amitriptyline and nortriptyline [72] [76] Oral contraceptives may increase the blood level of amitriptyline by as high as 90%. [77] Valproate moderately increases the levels of amitriptyline and nortriptyline through an unclear ...
Previous systematic reviews and meta-analyses had not comprehensively assessed TCAs in the same fashion, with the largest including only two TCAs (amitriptyline and clomipramine) and only 36 trials. [11] [12] A total of 103 short-term clinical trials with 10,590 participants employing 12 different TCAs (and TeCAs) were included. [11]
Nortriptyline (Pamelor, Aventyl) Noxiptiline (Agedal, Elronon, Nogedal) Pipofezine (Azafen/Azaphen) Protriptyline (Vivactil) Trimipramine (Surmontil) Opipramol (Insidon), tianeptine (Stablon, Coaxil) and amineptine (discontinued; formerly Survector, Maneon) are chemically TCAs but are pharmacodynamically atypical, and are therefore grouped ...
This is a list of psychiatric medications used by psychiatrists and other physicians to treat mental illness or distress.. The list is ordered alphabetically according to the condition or conditions, then by the generic name of each medication.
The second-generation antidepressants are a class of antidepressants characterized primarily by the era of their introduction, approximately coinciding with the 1970s and 1980s, rather than by their chemical structure or by their pharmacological effect.
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Other secondary amine TCAs include desipramine and nortriptyline. [ 26 ] [ 27 ] The chemical name of protriptyline is 3-(5 H -dibenzo[ a , d ][7]annulen-5-yl)- N -methylpropan-1-amine and its free base form has a chemical formula of C 19 H 21 N 1 with a molecular weight of 263.377 g/mol. [ 28 ] The drug is used commercially mostly as the ...