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  2. Melatonin as a medication and supplement - Wikipedia

    en.wikipedia.org/wiki/Melatonin_as_a_medication...

    Melatonin may be useful in the treatment of delayed sleep phase syndrome. [9] Melatonin is known to reduce jet lag, especially in eastward travel. However, if it is not taken at the correct time, it can instead delay adaptation. [30] Melatonin appears to have limited use against the sleep problems of people who work shift work. [31]

  3. Non-24-hour sleep–wake disorder - Wikipedia

    en.wikipedia.org/wiki/Non-24-hour_sleep–wake...

    Then, using endogenous melatonin as a marker for circadian rhythms, several research groups showed that appropriately timed melatonin administration could entrain free-running rhythms in the totally blind: they found that 6 out of 7 patients treated with 10 mg melatonin at bedtime were normally entrained, and when the dose was gradually reduced ...

  4. Melatonin - Wikipedia

    en.wikipedia.org/wiki/Melatonin

    Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.

  5. Taking melatonin for sleep? What to know about potential ...

    www.aol.com/news/taking-melatonin-sleep-know...

    Melatonin supplements for sleep come with side effects and their use may raise safety concerns, experts say. There's little evidence they help with insomnia.

  6. When Is the Best Time to Take Your Vitamin D? - AOL

    www.aol.com/best-time-vitamin-d-192000191.html

    While spending some solid time outside should help you meet your daily dose of 600 ... that vitamin D may impact your body’s production of melatonin, ... more) or conditions, Mayo Clinic notes.

  7. Is melatonin or ashwagandha better for sleep? Experts weigh in

    www.aol.com/finance/melatonin-ashwagandha-better...

    For those who wake up in the middle of the night, he recommends a sustained release of a higher dose of melatonin. To reap the sleep benefits of ashwagandha, he says the supplement must be at ...

  8. Ramelteon - Wikipedia

    en.wikipedia.org/wiki/Ramelteon

    Side effects of ramelteon include somnolence, dizziness, fatigue, nausea, exacerbated insomnia, and changes in hormone levels. [3] Ramelteon is an analogue of melatonin and is a selective agonist of the melatonin MT 1 and MT 2 receptors. [3] The half-life and duration of ramelteon are much longer than those of melatonin. [7]

  9. Agomelatine - Wikipedia

    en.wikipedia.org/wiki/Agomelatine

    Agomelatine acts as a highly potent and selective melatonin MT 1 and MT 2 receptor agonist (K i = 0.1 nM and 0.12 nM, respectively) and also as a relatively weak serotonin 5-HT 2B and 5-HT 2C receptor antagonist (K i = 660 nM and 631 nM, respectively; ~6,000-fold lower than for the melatonin receptors).

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