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The UNESCO study of publication trends in 193 countries on the topic of new or re-emerging viruses that can infect humans covered the period from 2011 to 2019 and now provides an overview of the state of research prior to the COVID-19 pandemic. Global output on this broad topic increased by only 2% per year between 2011 and 2019, slower than ...
COVID-19 vaccine clinical research uses clinical research to establish the characteristics of COVID-19 vaccines. These characteristics include efficacy , effectiveness , and safety. As of November 2022 [update] , 40 vaccines are authorized by at least one national regulatory authority for public use: [ 1 ] [ 2 ]
In May, the WHO announced an international coalition for simultaneously developing several candidate vaccines to prevent COVID-19 disease, calling this effort the Solidarity trial for vaccines. [ 4 ] The treatments being investigated are remdesivir , lopinavir/ritonavir combined, lopinavir/ritonavir combined with interferon-beta , and ...
The COVID-19 pandemic has accelerated research into RNA-based technologies, including saRNA. For instance, saRNA vaccines targeting SARS-CoV-2 have shown promising results in preclinical studies, indicating strong and durable immune responses with minimal adverse effects.
Today, a significant proportion of vaccines against viral diseases are created using nanotechnology. Solid lipid nanoparticles represent a novel delivery system for some vaccines against SARS-CoV-2 (the virus that causes COVID-19). [60] In recent decades, nanosized adjuvants have been widely used to enhance immune responses to targeted vaccine ...
As of late 2020, several mRNA vaccines for SARS-CoV-2 use LNPs as their drug delivery system, including both the Moderna COVID-19 vaccine and the Pfizer–BioNTech COVID-19 vaccines. [4] Moderna uses its own proprietary ionizable cationic lipid called SM-102, while Pfizer and BioNTech licensed an ionizable cationic lipid called ALC-0315 from ...
Intracellular delivery is a fundamental technique in the study of biology and genetics, such as the use of DNA plasmid transfection to investigate protein function in living cells. [10] A wide range of approaches exist for performing intracellular delivery including biological, chemical and physical techniques that work through either membrane ...
Acuitas Therapeutics Inc. is a Canadian biotechnology company based in Vancouver, British Columbia.The company was established in February 2009 to specialize in the development of delivery systems for nucleic acid therapeutics based on lipid nanoparticle (LNP) technology, a key component of the mRNA vaccines deployed for COVID-19.