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Marstacimab, sold under the brand name Hympavzi, is a monoclonal antibody medication used for the treatment of hemophilia A and hemophilia B. [1] [4] [2] It is a tissue factor pathway inhibitor (TFPI) antagonist. [4] It was developed by Pfizer. [5]
The most common side effects with Novoseven include venous thromboembolic events (problems caused by blood clots in the veins), rash, pruritus (itching), urticaria (hives), fever and reduced effectiveness of treatment. [4] The most common side effects with Cevenfacta include injection site discomfort and hematoma (a collection of blood under ...
Acquired haemophilia A (AHA) is a rare but potentially life-threatening bleeding disorder characterized by autoantibodies directed against coagulation factor VIII.These autoantibodies constitute the most common spontaneous inhibitor to any coagulation factor and may induce spontaneous bleeding in patients with no previous history of a bleeding disorder.
Hympavzi is the first and only anti-tissue factor pathway inhibitor (anti-TFPI) approved in the U.S. for hemophilia A or B and the first hemophilia medicine approved in the U.S. to be administered via
Concizumab, sold under the brand name Alhemo, is a monoclonal antibody used for the treatment of hemophilia A and hemophilia B. [5] [8] It is an anti-tissue factor pathway inhibitor. [5] [8] The most common adverse reactions include injection site reactions and hives (urticaria). [11]
Damoctocog alfa pegol, sold under the brand name Jivi is a recombinant DNA-derived, Factor VIII concentrate used to treat hemophilia A. [5] [6] The most common side effects include headache, cough, nausea, and fever. [5] Damoctocog alfa pegol was approved for medical use in the United States in August 2018, [7] and in the European Union in ...
Side effects include skin flushing, shortness of breath, fever, and red blood cell breakdown. [12] [13] Allergic reactions including anaphylaxis may occur. [13] It is unclear if use during pregnancy is safe for the fetus. [14] A purified factor VIII concentrate is made from human blood plasma. [13] A recombinant version is also available. [12]
In hemophilia A and von Willebrand disease, it should only be used for mild to moderate cases. [1] It may be given in the nose, by injection into a vein, by mouth, or under the tongue. [1] Common side effects include headaches, diarrhea, and low blood sodium. [1] The low blood sodium that results may cause seizures. [1]
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