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Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1]
Release (Liberation) is the first step in the process by which medication enters the body and liberates the active ingredient that has been administered. The pharmaceutical drug must separate from the vehicle or the excipient that it was mixed with during manufacture. Some authors split the process of liberation into three steps: disintegration ...
The pharmacological definition cannot apply to these substances because utilization and absorption is a function of the nutritional status and physiological state of the subject, [10] resulting in even greater differences from individual to individual (inter-individual variation). Therefore, bioavailability for dietary supplements can be ...
The substances may act on the drug's capsule to speed up drug release, or they may stimulate the body's absorptive surfaces to increase the rate of drug uptake. Dose dumping is a disadvantage found in extended release dosage form. In general, drug companies try to avoid drugs with significant dose dumping effects. Such drugs are prone to ...
A Florida woman who said she was playing a game with her boyfriend when she zipped him up in a suitcase and left him to die has been sentenced to life in prison.
Tachyphylaxis (Greek ταχύς, tachys, "rapid", and φύλαξις, phylaxis, "protection") is a medical term describing an acute, sudden decrease in response to a drug after its administration (i.e., a rapid and short-term onset of drug tolerance). [1] It can occur after an initial dose or after a series of small doses.
Post-Thanksgiving travel will be treacherous in parts of the Great Lakes region on Monday with more lake-effect snow falling after the region was already buried under feet of it, while cold ...
After chatter began that year about all of the artists lip-syncing, Kelly Clarkson was quick to confirm that her performance — and Brynn Cartelli's — was live. "Umm, I don't know if y'all know ...