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The Wiskott–Aldrich syndrome protein (WASp) is a 502-amino acid protein expressed in cells of the hematopoietic system that in humans is encoded by the WAS gene.In the inactive state, WASp exists in an autoinhibited conformation with sequences near its C-terminus binding to a region near its N-terminus.
The WH2 (WASP-Homology 2, or Wiskott–Aldrich homology 2) domain is an ~18 amino acids actin-binding motif. This domain was first recognized as an essential element for the regulation of the cytoskeleton by the mammalian Wiskott–Aldrich syndrome protein (WASP) family. WH2 proteins occur in eukaryotes from yeast to mammals, in insect viruses ...
8976 73178 Ensembl ENSG00000106299 ENSMUSG00000029684 UniProt O00401 Q91YD9 RefSeq (mRNA) NM_003941 NM_001167745 NM_028459 RefSeq (protein) NP_003932 NP_001161217 NP_082735 Location (UCSC) Chr 7: 123.68 – 123.75 Mb Chr 6: 24.61 – 24.67 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Neural Wiskott–Aldrich syndrome protein is a protein that in humans is encoded by the WASL gene ...
Despite the toxic effects to mammalian cells, mastoparan is also a potential antibiotic template due to its potent antimicrobial activity. In design study performed by Irazazabal and co-workers (2016), [4] it was demonstrated that the inclusion of an isoleucine and an arginine residue at positions 5 and 8 respectively [I5, R8], dramatically reduced the toxicity of mastoparan, turning it into a ...
In some species, the larvae are predatory themselves; the wasp eggs are deposited in clusters of eggs laid by other insects, and these are then consumed by the developing wasp larvae. [10] The largest social wasp is the Asian giant hornet, at up to 5 centimetres (2.0 in) in length. [11]
The emerald cockroach wasp stings the host for its larvae (a cockroach) in the head ganglion (brain). The venom blocks octopamine receptors [34] and the cockroach fails to show normal escape responses, grooming itself excessively. It becomes docile and the wasp leads it to the wasp's den by pulling its antenna like a leash. [35]
In 1963, Wilson, who the year before had already discovered the trace pheromones of ants, and William H. Bossert introduced the term releaser and primer pheromones for this purpose, to distinguish the behavior-controlling effect of, for example, sex attractants from the pheromones that interfere with the endocrine system of the receiver. [9] [10]
The results of various dose-response studies (10–60 mg) indicate a stimulating effect at lower doses, which diminishes as higher doses are administered. [13] Overall, the efficacy of thiothixene when compared to other antipsychotic drugs was evaluated to be at least as effective regardless of the optimum dosage.