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It is an aromatic amine. It is a component of a test for cyanide. ... Benzidine has been linked to bladder and pancreatic cancer. [2] Synthesis and properties
Crisnatol is a synthetic aromatic amine and a potent anticancer compound. It functions by intercalating into DNA and inhibiting topoisomerase activity, which leads to DNA damage and prevents cancer cells from proliferating.
As of 2006, tirapazamine is undergoing phase III testing in patients with head and neck cancer and gynecological cancer, and similar trials are being undertaken for other solid tumor types. [1] [2] Chemically it is an aromatic heterocycle di-N-oxide. Its full chemical name is 3-amino-1,2,4-benzotriazine-1,4 dioxide.
In organic chemistry, an aromatic amine is an organic compound consisting of an aromatic ring attached to an amine. It is a broad class of compounds that encompasses anilines , but also many more complex aromatic rings and many amine substituents beyond NH 2 .
Chlornaphazine, a derivative of 2-naphthylamine, is a nitrogen mustard that was developed in the 1950s for the treatment of polycythemia and Hodgkin's disease. [1] However, a high incidence of bladder cancers in patients receiving treatment with chlornaphthazine led to use of the drug being discontinued.
The elimination half-life of the drug is 12,5 hours and 34-54% of the drug is excreted unchanged in the urine. [23] Anastrozole is administered orally and has a standard daily dose of 1 mg. Anastrozole has good oral bioavailability and is rapidly absorbed. It takes 2–3 hours for the drug to reach maximum serum concentration.
Lynparza patients had a 79.6% IDFS rate at six years, compared to 70.3% for placebo patients, with the drug reducing the risk of invasive breast cancer recurrence, second cancers, or death by 35%.
Niacin, essential to many types of life, is an example of a heterocyclic amine. Heterocyclic amines , also sometimes referred to as HCA s, are chemical compounds containing at least one heterocyclic ring, which by definition has atoms of at least two different elements, as well as at least one amine (nitrogen-containing) group.