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Amyloid beta (Aβ, Abeta or beta-amyloid) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. [2] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol ...
Alzheimer's first substantive description of plaques appeared in 1911. [11] ... Amyloid beta (Aβ) is a small protein, most often 40 or 42 amino acids in length, ...
The cause for most Alzheimer's cases is still mostly unknown, [14] except for 1–2% of cases where deterministic genetic differences have been identified. [17] Several competing hypotheses attempt to explain the underlying cause; the most predominant hypothesis is the amyloid beta (Aβ) hypothesis. [14]
A main theory behind the cause of Alzheimer’s disease is the build-up of the protein amyloid-beta in the brain. Researchers from the University of Cincinnati provide evidence suggesting it’s ...
New research is contradicting previously held views that only neurons secret beta-amyloid that forms toxic plaques, a marker of Alzheimer's disease in the brain. The study points to another ...
The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy: a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain. [1]
A new study distinguishes between two distinct phases of Alzheimer's ... The researcheres found that a score of 0.4-0.6 was when pTau and beta-amyloid accumulation increased dramatically and ...
Amyloid beta (Aβ) is composed of a family of peptides produced by proteolytic cleavage of the type I transmembrane spanning glycoprotein amyloid-beta precursor protein (APP). Amyloid plaque Aβ protein species ends in residue 40 or 42, [ 4 ] but it is suspected that Aβ42 form is crucial in the pathogenesis of AD.
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