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Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. [3] Serious side effects include Clostridioides difficile infection, seizures, and allergic reactions including anaphylaxis. [3] Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well. [3]
Severe side effects may include anaphylaxis, seizures, and Clostridioides difficile-associated diarrhea. [3] It is unclear if use during pregnancy is safe. [4] Meropenem works by blocking the construction of the bacterial cell wall while vaborbactam blocks the breakdown of meropenem by some beta-lactamases. [3]
The carbapenems imipenem and meropenem are recommended by the American Thoracic Society and the Infectious Disease Society of America as one of several first-line therapy options for people with late-onset hospital-acquired or ventilator-associated pneumonia, especially when Pseudomonas, Acinetobacter, or extended spectrum beta-lactamase ...
For both women, the family of antibiotics known as fluoroquinolones resulted in pain and nerve damage. ... there have been 45,000 reported cases of side effects related to fluoroquinolones. 23.1 ...
Vaborbactam [1] is a non-β-lactam β-lactamase inhibitor discovered by Rempex Pharmaceuticals, a subsidiary of The Medicines Company. While not effective as an antibiotic by itself, it restores potency to existing antibiotics by inhibiting the β-lactamase enzymes that would otherwise degrade them.
Effective for gram-positive, gram-negative, anaerobic, and against multi-antibiotic resistant bacteria (such as Staphylococcus aureus [MRSA] and Acinetobacter baumannii), but not effective for Pseudomonas spp. and Proteus spp. Teeth discoloration and same side effects as tetracycline. Not to be given to children and pregnant or lactating women.
Phage therapy against P. aeruginosa has been investigated as a possible effective treatment, which can be combined with antibiotics, has no contraindications and minimal adverse effects. Phages are produced as sterile liquid, suitable for intake, applications etc. [ 113 ] Phage therapy against ear infections caused by P. aeruginosa was reported ...
The ureidopenicillins are a group of penicillins which are active against Pseudomonas aeruginosa. [citation needed] There are three ureidopenicillins in clinical use: [1] Azlocillin; Piperacillin; Mezlocillin; They are mostly ampicillin derivatives in which the amino acid side chain has been converted to a variety of cyclic ureas.