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Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
Of these, amoxicillin-clavulanate is the most common cause of drug-induced liver injury, and paracetamol toxicity the most common cause of acute liver failure in the United States and Europe. [37] Herbal remedies and dietary supplements are another important cause of hepatitis; these are the most common causes of drug-induced hepatitis in Korea ...
Hepatoprotection or antihepatotoxicity is the ability of a chemical substance to prevent damage to the liver. This is opposite to hepatotoxicity . Hepatoprotective molecules used in emergency medicine
Paracetamol toxicity is one of the most common causes of poisoning worldwide. [25] In the United States, the United Kingdom, Australia, and New Zealand, paracetamol is the most common cause of drug overdoses. [20] [92] [93] Additionally, in both the United States and the United Kingdom it is the most common cause of acute liver failure. [94] [9]
In terms of drug-drug interactions, acetaminophen activates CAR, a nuclear receptor involved in the production of metabolic enzymes, which increases the metabolism of other drugs. This could either cause reactive intermediates/drug activity to persist for longer than necessary, or the drug will be cleared quicker than normal and prevent any ...
The study itself notes that actual green tea rarely causes any problems for otherwise healthy individuals, but that concentrated green tea extract—often found in unregulated herbal supplements ...
Drugs and other substances that have been associated with significant hepatotoxicity (liver damage). Subcategories ...
Hepatitis B vaccine can prevent hepatitis B and the development of cirrhosis from it, but no vaccination against hepatitis C is available. [1] No specific treatment for cirrhosis is known, but many of the underlying causes may be treated by medications that may slow or prevent worsening of the condition. [ 3 ]