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Topical nifedipine has been shown to be as effective as topical nitrates for anal fissures. [18] Nifedipine is also used in high-altitude medicine to treat high altitude pulmonary edema. [19] Nifedipine is one of the main choices for the treatment of Prinzmetal angina due to its vasodilating effects on the coronary arteries. [2]
Hypertensive disease of pregnancy, also known as maternal hypertensive disorder, is a group of high blood pressure disorders that include preeclampsia, preeclampsia superimposed on chronic hypertension, gestational hypertension, and chronic hypertension. [3] Maternal hypertensive disorders occurred in about 20.7 million women in 2013. [1]
Drug treatment options are limited, as many antihypertensives may negatively affect the fetus. ACE inhibitors, angiotensin receptor blockers, and direct renin inhibitors are contraindicated in pregnancy as they are teratogenic. Methyldopa, hydralazine, nifedipine, and labetalol are most commonly used for severe pregnancy hypertension. [7]
The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. [3]
Labetalol, hydralazine and nifedipine are commonly used antihypertensive agents for hypertension in pregnancy. [6] ACE inhibitors and angiotensin receptor blockers are contraindicated as they affect fetal development. [54] The goal of treatment of severe hypertension in pregnancy is to prevent cardiovascular, kidney, and cerebrovascular ...
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
They are used in the treatment of hypertension. [2] Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, the dihydropyridine calcium channel blockers lower blood pressure mainly by relaxing the smooth muscle of the blood vessel ...
Low dose aspirin is recommended to prevent pre-eclampsia and eclampsia in those at high risk. [12] Other preventative recommendations include calcium supplementation in areas with low calcium intake and treatment of prior hypertension with anti-hypertensive medications. [2] [3] Exercise during pregnancy may also be useful. [1]