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Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
Non-HFE associated hemochromatosis, as Haemochromatosis type 2, Haemochromatosis type 3, Haemochromatosis type 4 and Haemochromatosis type 5, [10] were discovered in Mediterranean countries. On the other side, Northern European ancestry is closely linked to hereditary hemochromatosis disease (HFE).
Treatment for hemochromatosis type 3 may include reducing iron levels by removing blood (phlebotomy), iron chelation therapy, diet changes, and treatment for complications of the disease. The purpose of the treatment is to reduce the amount of iron in the body to normal levels, prevent or delay organ damage from excess iron, and maintain normal ...
Dr. Wasan shares that there are several organs located on the right side of the body that can cause pain, including the lungs, gallbladder, pancreas, appendix, colon or even kidneys.
Digestive issues such as acid reflux can radiate pain into the right side of the chest. Several musculoskeletal problems, such as broken ribs and pulled chest or back muscles can also result in pain.
Pain on the upper right side can also be a sign of a kidney issue. We have two kidneys, one on either side of the body, and the right kidney is situated just under the liver.
Hemochromatosis type 4 is a hereditary iron overload disorder that affects ferroportin, an iron transport protein needed to export iron from cells into circulation. [1] Although the disease is rare, it is found throughout the world and affects people from various ethnic groups.
Certain metabolic disorders, such as hemochromatosis (extra iron buildup in the body), can cause or contribute to testosterone deficiency by affecting pituitary or hypothalamic function. Alcohol ...
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