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Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative. It is a first-generation H 1 -antihistamine and it works by blocking certain effects of histamine , which produces its antihistamine and sedative effects.
An FAA report found that between 2012 and 2016, diphenhydramine was the most common pharmaceutical known to cause impairment detected in post-mortem toxicology tests performed on someone who may have been in charge of the aircraft at the time of a fatal plane crash, specifically naming both Benadryl and Sominex. [65]
Benadryl can also be found in a topical form including gels and creams. Benadryl Itch Stopping Cream is a topical cream used to provide temporary itch relief for allergies, hives or even some insect bites. It can be found in the United States and Canada. This topical medication contains 2% of diphenhydramine hydrochloride and 1% of zinc acetate.
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