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Furosemide, sold under the brand name Lasix among others, is a loop diuretic medication used to treat edema due to heart failure, liver scarring, or kidney disease. [4] Furosemide may also be used for the treatment of high blood pressure. [4] It can be taken intravenously or orally. [4]
This causes an increase in renal free water excretion (aquaresis), an increase in serum sodium concentration, a decrease in urine osmolality, and an increase in urine output. [16] 5. collecting duct: Na-H exchanger antagonists: dopamine [17] Promotes Na + excretion 2. proximal tubule [17] Carbonic anhydrase inhibitors: acetazolamide, [17 ...
This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte abnormalities. It was patented in 1966 and approved for medical use in 1974. [1]
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Compared with furosemide, torasemide is associated with a lower risk of rehospitalization for heart failure and an improvement in New York Heart Association class of heart failure. [ 7 ] [ 8 ] [ 9 ] In heart failure it may be safer and more effective than furosemide .
A Lilly-sponsored head-to-head trial earlier in December reinforced findings from separate studies that Zepbound yielded greater weight loss over 72 weeks, on average, than Wegovy — 20% compared ...