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MAP2K1 is also known as MEK1 (see Mitogen-activated protein kinase kinase). MEK1 is a meiotic chromosome-axis-associated kinase that is thought to slow down, but not entirely block, sister chromatid recombination. Loss of MEK1 allows inter-sister DSB repair and also inter-sister Holliday junction intermediates to increase.
Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a dual-specificity kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK). ...
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of serine/threonine-specific protein kinases involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines.
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Perhaps the best characterized MAP3K are the members of the oncogenic RAF family (RAF1, BRAF, ARAF), which are effectors of mitogenic ras signaling and which activate the ERK1/2 (MAPK3/MAPK1) pathway, through activation of MEK1(MAP2K1) and MEK2(MAP2K2). The JNKs are regulated by the MEKK 1/4, MLK 2/3, and ASK 1 MAPKKKs.
5605 26396 Ensembl ENSG00000126934 ENSMUSG00000035027 UniProt P36507 Q63932 RefSeq (mRNA) NM_030662 NM_023138 NM_001347144 NM_001358539 RefSeq (protein) NP_109587 NP_001334073 NP_075627 NP_001345468 Location (UCSC) Chr 19: 4.09 – 4.12 Mb Chr 10: 80.94 – 80.97 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme ...
8649 56692 Ensembl ENSG00000109270 ENSMUSG00000091512 UniProt Q9UHA4 O88653 RefSeq (mRNA) NM_001243736 NM_021970 NM_019920 RefSeq (protein) NP_001230665 NP_068805 NP_064304 Location (UCSC) Chr 4: 99.88 – 99.89 Mb Chr 3: 137.62 – 137.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitogen-activated protein kinase scaffold protein 1 is a scaffold protein that in humans is ...