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Because it contains free iodine, Lugol's solution at 2% or 5% concentration without dilution is irritating and destructive to mucosa, such as the lining of the esophagus and stomach. Doses of 10 mL of undiluted 5% solution have been reported to cause gastric lesions when used in endoscopy. [ 20 ]
USP Tincture of Iodine is defined in the U.S. National Formulary (NF) as containing in each 100 mL, 1.8 to 2.2 grams of elemental iodine, and 2.1 to 2.6 grams of sodium iodide. Alcohol is 50 mL, and the balance is purified water. This "2% free iodine" solution has 0.08 mol/L of I 2, which provides about 1 mg of free iodine per 0.05 mL drop. The ...
In 1923 the American physician Henry Stanley Plummer discovered that high-dose iodine may be effective in the treatment of Graves’ disease. [2] [3] Today, “Plummering”, i.e. therapy with Lugol's iodine solution, is one of several emergency measures in the management of severe thyrotoxicosis. [4]
Like other iodide salts, KI forms triiodide (I − 3) when combined with elemental iodine. KI (aq) + I 2 (s) → KI 3 (aq) Unlike I 2, I − 3 salts can be highly water-soluble. Through this reaction, iodine is used in redox titrations. Aqueous KI 3 (Lugol's iodine) solution is used as a disinfectant and as an etchant for gold surfaces.
Unlike tincture of iodine, Lugol's iodine has a minimised amount of the free iodine (I 2) component. Iodine glycerin, a preparation used in dentistry. Povidone iodine (an iodophor). Iodine-V: iodine (I 2) and fulvic acid form a clathrate compound (iodine molecules are "caged" by fulvic acid in this host-guest complex). A water-soluble, solid ...
[2] Povidone-iodine is a chemical complex of povidone, hydrogen iodide, and elemental iodine. [4] The recommended strength solution contains 10% Povidone, with total iodine species equaling 10,000 ppm or 1% total titratable iodine. [4] It works by releasing iodine which results in the death of a range of microorganisms. [1]
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