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Paget's disease may affect any one or several bones of the body (most commonly pelvis, tibia, femur, lumbar vertebrae, and skull), but never the entire skeleton, [1] [2] [3] and does not spread from bone to bone. [4] Rarely, a bone affected by Paget's disease can transform into a malignant bone cancer.
Paget’s disease of bone is a chronic disorder characterized by abnormal bone remodeling. The pelvic brim sign arises due to excessive bone resorption due to increased osteoclastic activity in the early stages of the disease leads to localized bone loss, as well as excessive bone formation during the later stages of the diseases.
The thyroid, parathyroid, pituitary, or adrenal glands, and the pancreas are parts of the endocrine system, and, therefore are associated with the endocrine bone disease. [2] Some common endocrine disorders are hypothyroidism, hyperthyroidism, Paget's disease, [1] Osteoporosis, and diabetes. [3]
Platybasia is a spinal disease of a malformed relationship between the occipital bone and cervical spine. It may be caused by Paget's disease. Platybasia is also a feature of Gorlin-Goltz syndrome, commonly known as basal cell nevus syndrome. It may be developmental in origin or due to softening of the skull base bone, allowing it to be pushed ...
Blade of grass sign (also known as flame sign [1]) is a radiologic sign referring to the lytic fronts seen in the leading edge of the long bone in Paget's disease. [2] It is usually seen as a wedge shaped area of radiolucency in the diaphysis of long bone. [1]
Bone disease refers to the medical conditions which affect the bone. [1] Terminology ... (or Paget's disease of bone) [16]
Leprosy, Paget's disease of bone Leonine facies is a facies that resembles that of a lion . It is seen in multiple conditions and has been classically described for lepromatous leprosy as well as Paget's disease of bone .
Multisystem proteinopathy (MSP) is a dominantly inherited, pleiotropic, degenerative disorder of humans that can affect muscle, bone, and/or the central nervous system.MSP can manifest clinically as classical amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), inclusion body myopathy (IBM), Paget's disease of bone (PDB), or as a combination of these disorders. [1]