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The structure and function of the epithelial cells lining the lumen change during the course of the nephron, and have segments named by their location and which reflects their different functions. Fig.4) Diagram outlining movement of ions in nephron, with the collecting ducts on the right.
The nephron is the structural and functional unit of the kidney. Each adult human kidney contains around 1 million nephrons, while a mouse kidney contains only about 12,500 nephrons. The kidneys also carry out functions independent of the nephrons.
The metanephridia, together with the vascular filtration site and coelom, are functionally identical to the ancestral primitive kidneys of vertebrates. [14] The main structural and functional element of the kidney is the nephron. [15] Between animals, the kidneys can differ in the number of nephrons and in their organisation. [16]
Each nephron begins in a renal corpuscle, which is composed of a glomerulus enclosed in a Bowman's capsule. Cells, proteins, and other large molecules are filtered out of the glomerulus by a process of ultrafiltration , leaving an ultrafiltrate that resembles plasma (except that the ultrafiltrate has negligible plasma proteins ) to enter Bowman ...
There are two poles in the renal corpuscle, a vascular pole and a tubular pole. [4] The vascular pole is a location of the glomerulus. At the vascular pole, the afferent arterioles and efferent arterioles enter and leave the glomerulus in the Bowman's capsule. The tubular pole is at the other end opposite to the vascular pole.
The right passes behind the inferior vena cava, the right renal vein, the head of the pancreas, and the descending part of the duodenum. It’s somewhat lower than the left one. Left artery lies behind the left renal vein, the body of the pancreas and the splenic vein, and is crossed by the inferior mesenteric vein.
The renal circulation supplies the blood to the kidneys via the renal arteries, left and right, which branch directly from the abdominal aorta.Despite their relatively small size, the kidneys receive approximately 20% of the cardiac output.
The nephron is composed of a renal corpuscle and a renal tubule. The renal corpuscle is a blood-filtering part of the nephron and is located in the cortex. The renal tubule extends from the renal corpuscle to the medulla into the loop of Henle and then returns back to the cortex. Finally, the renal tubule flows with its distal end into its ...