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The dental follicle, also known as dental sac, is made up of mesenchymal cells and fibres surrounding the enamel organ and dental papilla of a developing tooth. [1] It is a vascular fibrous sac [2] containing the developing tooth and its odontogenic organ. The dental follicle (DF) differentiates into the periodontal ligament.
A condensation of ectomesenchymal cells called the dental sac or follicle surrounds the enamel organ and limits the dental papilla. Eventually, the enamel organ will produce enamel, the dental papilla will produce dentin and pulp, and the dental sac will produce all the supporting structures of a tooth, the periodontium. [1]
The cells are part of the reduced enamel epithelium after enamel maturation and then subsequently undergo apoptosis before or after tooth eruption. [ 2 ] [ 3 ] : 103 These stages occur during the third and final stage of amelogenesis , called the maturation phase.
Tooth development begins at week 6 in utero, in the oral epithelium. The process is divided into three stages: Initiation; Morphogenesis and; Histogenesis [2]; At the end of week 7 i.u., localised proliferations of cells in the dental laminae form round and oval swellings known as tooth buds, which will eventually develop into mesenchymal cells and surround the enamel organ.
The dental papilla contains cells that develop into odontoblasts, which are dentin-forming cells. [27] Additionally, the junction between the dental papilla and inner enamel epithelium determines the crown shape of a tooth. [28] The dental follicle gives rise to three important cells: cementoblasts, osteoblasts, and fibroblasts. Cementoblasts ...
The dental follicle → The ectomesenchymal cells which are part of the fibrous sac that have been formed; The dental papilla → The ectomesenchymal cells which are lying deep to the enamel organ; The enamel organ → purely the epithelial component; The tissues which have been derived from each of the three components are:
Some of the hormone-related dental problems may begin during perimenopause, when the ovaries gradually make less estrogen. Hot flashes and night sweats are among the most infamous menopause maladies .
In animal tooth development, the inner enamel epithelium, also known as the internal enamel epithelium, is a layer of columnar cells located on the rim nearest the dental papilla of the enamel organ in a developing tooth. This layer is first seen during the cap stage, in which these inner enamel epithelium cells are pre-ameloblast cells.