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RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme [4] that in humans is encoded by the RAF1 gene. [ 5 ] [ 6 ] The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase (MAP3K) that functions downstream of the Ras subfamily of membrane associated GTPases. [ 7 ]
RAF is an acronym for Rapidly Accelerated Fibrosarcoma. [12] RAF kinases participate in the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade. [11] Activation of RAF kinases requires interaction with RAS-GTPases. The three RAF kinase family members are: A-RAF; B-RAF; c-Raf
The CSE was formed 1 September 1946 at RAF Watton, equipped with Dominie and Tiger Moth, and disbanded there on 1 July 1965. [3] When the establishment disbanded, the Research Wing and civilian parts of the "..Installation Squadron became the RAF Signals Command Air Radio Laboratories, and the training and service elements of Installation ...
Activated Ras then activates the protein kinase activity of a RAF kinase. [4] The RAF kinase phosphorylates and activates a MAPK/ERK Kinase (MEK1 or MEK2). The MEK phosphorylates and activates a mitogen-activated protein kinase (MAPK). RAF and MAPK/ERK are both serine/threonine-specific protein kinases. MEK is a serine/tyrosine/threonine kinase.
The Royal Air Force (RAF) is the air and space force of the United Kingdom, British Overseas Territories and Crown Dependencies. [7] It was formed towards the end of the First World War on 1 April 1918, on the merger of the Royal Flying Corps (RFC) and the Royal Naval Air Service (RNAS). [8]
The Red Army Faction (German: Rote Armee Fraktion, pronounced [ˌʁoːtə ʔaʁˈmeː fʁakˌtsi̯oːn] ⓘ; RAF [ˌɛʁʔaːˈʔɛf] ⓘ), [a] also known as the Baader–Meinhof Group or Baader–Meinhof Gang (German: Baader-Meinhof-Gruppe Baader-Meinhof-Bande [ˈbaːdɐ ˈmaɪnhɔf ˈɡʁʊpə] ⓘ), was a West German far-left militant group founded in 1970 and active until 1998.
1: RAF Cranfield Communications Flight Avro 619 Five: 1: No. 11 Air Observer Navigation School (AONS) at RAF Hamble: Beech 17 Traveller: 4: Bellanca Pacemaker: 1: British Aircraft Double Eagle: 2: British Aircraft Eagle [238] 4: British Aircraft Swallow [238] 9: some converted into gliders British Aircraft Company Drone: 1: 608 Squadron ...
The RAF 1 is a British air-cooled, V-8 engine developed for aircraft use during World War I. Based on a French design, it was developed at the Royal Aircraft Factory , and built by six different British companies including Daimler , Rolls-Royce and Wolseley Motors Limited .