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Pinocytosis. In cellular biology, pinocytosis, otherwise known as fluid endocytosis and bulk-phase pinocytosis, is a mode of endocytosis in which small molecules dissolved in extracellular fluid are brought into the cell through an invagination of the cell membrane, resulting in their containment within a small vesicle inside the cell.
The destruction of microvilli can actually be beneficial sometimes, as in the case of elimination of microvilli on white blood cells which can be used to combat auto immune diseases. [ 6 ] Congenital lack of microvilli in the intestinal tract causes microvillus atrophy , a rare, usually fatal condition found in new-born babies.
The endothelium provides a smooth surface for the flow of blood and regulates the movement of water and dissolved materials in the interstitial plasma between the blood and the tissues. The microcirculation contrasts with macrocirculation, which is the circulation of blood to and from the organs.
Other cellular extensions that protrude from the cell membrane are known as membrane protrusions or cell protrusions, also cell appendages, such as flagella, and microvilli. [8] [9] Microtentacles are cell protrusions attached to free-floating cells, associated with the spread of some cancer cells. [10]
The vesicle then travels into the cytosol and fuses with other vesicles such as endosomes and lysosomes. [ 9 ] Phagocytosis is the process by which cells bind and internalize particulate matter larger than around 0.75 μm in diameter, such as small-sized dust particles, cell debris, microorganisms and apoptotic cells.
The release of microvesicles has been shown from endothelial cells, vascular smooth muscle cells, platelets, white blood cells (e.g. leukocytes and lymphocytes), and red blood cells. Although some of these microvesicle populations occur in the blood of healthy individuals and patients, there are obvious changes in number, cellular origin, and ...
Differences in vascular permeability between normal tissue and a tumor. Vascular permeability, often in the form of capillary permeability or microvascular permeability, characterizes the capacity of a blood vessel wall to allow for the flow of small molecules (drugs, nutrients, water, ions) or even whole cells (lymphocytes on their way to the site of inflammation) in and out of the vessel.
Capillary blood sampling can be used to test for blood glucose (such as in blood glucose monitoring), hemoglobin, pH and lactate. [ 30 ] [ 31 ] It is generally performed by creating a small cut using a blood lancet , followed by sampling by capillary action on the cut with a test strip or small pipette . [ 32 ]