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Preliminary trial results found a greater weight loss compared to either medication alone. HbA1c was significantly improved compared to cagrilintide alone and non-significantly better than semaglutide alone. [1] [2] In a Phase II trial, weight loss averaged -15.6 percent after 32 weeks, making CagriSema comparable in efficacy to tirzepatide.
These drugs are developed for the same indications as GLP-1 receptor agonists—especially obesity, type 2 diabetes, and non-alcoholic fatty liver disease. They are expected to provide superior efficacy with fewer adverse effects compared to GLP-1 mono-agonists, which are dose-limited by gastrointestinal disturbances. [ 2 ]
Ozempic is an FDA-approved medication for people who have type 2 diabetes. It’s often prescribed “off-label” for weight loss — when a drug is prescribed for something it’s not approved for.
Here’s what to keep in mind about type 2 diabetes medications used to support weight loss and weight loss injections: Weight loss injections are safe and effective when used as prescribed .
Mazdutide (also known as IBI362 or LY3305677) is a dual agonist of the GLP-1 receptor and glucagon receptor. It is an analog of oxyntomodulin (OXM). [ 1 ] [ 2 ] [ 3 ] The drug is developed by Eli Lilly and is currently in multiple Phase III studies.
First approved by the Food and Drug Administration (FDA) in 2017 to treat Type 2 diabetes, Ozempic became a household name over time and a social media topic of discussion for its weight loss ...
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