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The World Health Organisation has stated that depression is a leading cause of disability worldwide and a major contributor to the global burden of disease. [5] Stephen Ilardi has described depression as a "disease of civilisation", stating "We were never designed for the sedentary, indoor, sleep-deprived, socially-isolated, fast-food-laden, frenetic pace of modern life".
Sequenced Treatment Alternatives to Relieve Depression (STAR*D) was a collaborative study on the treatment of depression, funded by the National Institute of Mental Health. Its main focus was on the treatment of depression in patients where the first prescribed antidepressant proved inadequate.
The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...
plan of treatment POTS: postural orthostatic tachycardia syndrome: POX: peroxidase: PP: pulse pressure postpartum, that is, postnatal postprandial: PPCS: prolonged post-concussion syndrome: PPD: packs per day postpartum depression, that is, postnatal depression purified protein derivative or Mantoux test, for tuberculosis testing PPE
It may cause depressed patients to be noncompliant in their treatment, and the effects of certain substances can worsen the effects of depression. Other psychiatric disorders that may predict treatment-resistant depression include attention deficit hyperactivity disorder , [ 7 ] personality disorders , obsessive compulsive disorder , and eating ...
Several treatment guidelines recommend pharmaceutical treatments that include either the combination of a second-generation antidepressant and atypical antipsychotic or tricyclic antidepressant monotherapy or electroconvulsive therapy (ECT) as the first-line treatment for unipolar psychotic depression.
Psychotic major depression (PMD), or simply psychotic depression, is the term for a major depressive episode, in particular of melancholic nature, wherein the patient experiences psychotic symptoms such as delusions or, less commonly, hallucinations. These are most commonly mood-congruent (content coincident with depressive themes). [16]
Meta-analyses suggest that the combination of psychotherapy and antidepressant medications is more effective in treating mild and moderate forms of depression than either type of treatment alone. [27] Patients with severe symptoms may require outpatient treatment or hospitalization. [7] The treatment of a major depressive episode can be split ...
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