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Thomas Addison (April 1795 – 29 June 1860) was an English physician and medical researcher. He is traditionally regarded as one of the "great men" of Guy's Hospital in London. Thomas Addison began his career at Guy's Hospital in 1817, eventually becoming a full physician in 1837.
A case of anemia with a first recognition of associated atrophic gastritis a feature of pernicious anemia, was first described in 1824 by James Combe. This was fully investigated in 1849, by British physician Thomas Addison, from which it acquired the common name of Addison's anemia.
The disease referred to a chronic progressive adrenal insufficiency, and was described in 1855 by the Englishman Thomas Addison, who gave it his name, Addison's disease. [9] The cardinal signs included asthenia , low blood pressure , anorexia (with weight loss) and melanoderma, with hyperpigmentation of the skin at friction points and of the ...
Addison's disease: Adrenal glands: 21-hydroxylase antibodies Confirmed 0.93-1.4 per 10,000 [72] Autoimmune oophoritis: Ovaries: Anti-ovarian antibodies Probable Rare [73] Autoimmune orchitis: Testes: Anti-sperm antibodies Probable Rare [74] Autoimmune pancreatitis: Pancreas: IgG4, Anti-CA2 antibodies Confirmed 0.82-1.3 per 100,000 [75]
Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow ...
Nutritional anemia can be caused by a lack of iron, protein, vitamin B12, and other vitamins and minerals that are needed for the formation of hemoglobin. However, Iron deficiency anemia is the most common nutritional disorder. [7] Signs of anemia include cyanosis, jaundice, and easy bruising. [7]
He called it "pernicious anemia" because of the disease's insidious course, and because it was deemed to be untreatable at the time. In 1849, Thomas Addison described the same disease, however Biermer's description was much more comprehensive. Historically, pernicious anemia has also been called "Addison-Biermer disease".
At the autopsy, where he was assisted by Kellie, he found the stomach was "thin, showing no vessels and transparent", a description of atrophic gastritis, which is a distinctive feature of pernicious anaemia, and preceded Dr Thomas Addison’s admittedly fuller account by 27 years. Although the condition bears Addison's name, Combe's was the ...