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Several drug classes are indicated for use in type 2 diabetes and are often used in combination. Therapeutic combinations may include several insulin isoforms or varying classes of oral antihyperglycemic agents. As of 2020, 23 unique antihyperglycemic drug combinations were approved by the FDA. [1]
Alpha-glucosidase inhibitors ( AGIs) are oral anti-diabetic drugs used for diabetes mellitus type 2 that work by preventing the digestion of carbohydrates (such as starch and table sugar ). Carbohydrates are normally converted into simple sugars ( monosaccharides) by alpha-glucosidase enzymes present on cells lining the intestine, enabling ...
The American Diabetes Association and the American College of Physicians both recommend metformin as a first-line agent to treat type 2 diabetes. [34] [35] [36] It is as effective as repaglinide and more effective than all other oral drugs for type 2 diabetes. [37]
Glimepiride is an antidiabetic medication within the sulfonylurea class, primarily prescribed for the management of type 2 diabetes. [ 1][ 2] It is regarded as a second-line option compared to metformin, due to metformin's well-established safety and efficacy. [ 1] Use of glimepiride is recommended in conjunction with lifestyle modifications ...
Treatment for type 2 diabetes is often oral medication such as metformin, or increasingly glucagon-like peptide 1 (GLP-1) agonists, which also treat obesity.
Dipeptidyl peptidase-4 inhibitor. Inhibitors of dipeptidyl peptidase 4 ( DPP-4 inhibitors or gliptins) are a class of oral hypoglycemics that block the enzyme dipeptidyl peptidase-4 (DPP-4). They can be used to treat diabetes mellitus type 2 . The first agent of the class – sitagliptin – was approved by the FDA in 2006.
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