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Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke, heart failure, kidney failure and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34% and of ischaemic heart disease by 21%, and can reduce the likelihood of dementia ...
The antihypertensive actions of some diuretics (thiazides and loop diuretics in particular) are independent of their diuretic effect. [ 1 ] [ 2 ] That is, the reduction in blood pressure is not due to decreased blood volume resulting from increased urine production , but occurs through other mechanisms and at lower doses than that required to ...
Hydrochlorothiazide. Hydrochlorothiazide, sold under the brand name Hydrodiuril among others, is a diuretic medication used to treat hypertension and swelling due to fluid build-up. [ 4] Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those with a high calcium level in the ...
Potassium-sparing diuretics or antikaliuretics[ 1] refer to drugs that cause diuresis without causing potassium loss in the urine. [ 2] They are typically used as an adjunct in management of hypertension, cirrhosis, and congestive heart failure. [ 3] The steroidal aldosterone antagonists can also be used for treatment of primary hyperaldosteronism.
Thiazide ( / ˈθaɪəzaɪd /) refers to both a class of sulfur-containing organic molecules [ 1] and a class of diuretics based on the chemical structure of benzothiadiazine. [ 2] The thiazide drug class was discovered and developed at Merck and Co. in the 1950s. [ 3] The first approved drug of this class, chlorothiazide, was marketed under ...
Furosemide. Furosemide is a loop diuretic medication used to treat edema due to heart failure, liver scarring, or kidney disease. [ 4] It has had many trade names including Discoid, Frusemide, Lasix and Uremide. Furosemide may also be used for the treatment of high blood pressure. [ 4]
Indapamide is a thiazide-like diuretic [ 4] drug used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are available. The thiazide-like diuretics (indapamide and chlorthalidone) reduce risk of major cardiovascular events and heart failure in ...
Mineralocorticoid receptor antagonists are diuretic drugs that work primarily on the kidneys. They decrease sodium reabsorption , which leads to increased water excretion by the kidneys . [ 2 ] By regulating water excretion, mineralocorticoid receptor antagonists lower blood pressure and reduce fluid around the heart which can be very ...
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