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Loop diuretics are 90% bonded to proteins and are secreted into the proximal convoluted tubule through organic anion transporter 1 (OAT-1), OAT-2, and ABCC4. Loop diuretics act on the Na + -K + -2Cl − symporter (NKCC2) in the thick ascending limb of the loop of Henle to inhibit sodium, chloride and potassium reabsorption.
Furosemide is a loop diuretic medication used to treat edema due to heart failure, liver scarring, or kidney disease. [4] It has had many trade names including Discoid, Frusemide, Lasix and Uremide. Furosemide may also be used for the treatment of high blood pressure. [4] It can be taken intravenously or orally. [4]
Loop diuretics have this ability, and are therefore often synonymous with high-ceiling diuretics. Loop diuretics, such as furosemide , inhibit the body's ability to reabsorb sodium at the ascending loop in the nephron , which leads to an excretion of water in the urine, whereas water normally follows sodium back into the extracellular fluid.
Etacrynic acid. Etacrynic acid ( INN) or ethacrynic acid ( USAN ), trade name Edecrin, is a loop diuretic used to treat high blood pressure and the swelling caused by diseases like congestive heart failure, liver failure, and kidney failure. A con with ethacrynic acid compared to the other loop diuretic drugs such as furosemide is that it has a ...
Metolazone is a thiazide-like diuretic marketed under the brand names Zytanix, Metoz, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases.
Potassium-sparing diuretics or antikaliuretics[ 1] refer to drugs that cause diuresis without causing potassium loss in the urine. [ 2] They are typically used as an adjunct in management of hypertension, cirrhosis, and congestive heart failure. [ 3] The steroidal aldosterone antagonists can also be used for treatment of primary hyperaldosteronism.
Diuretics. Loop diuretics like furosemide and bumetanide, and thiazide diuretics like hydrochlorothiazide and ethacrynic acid can cause magnesium depletion. Potassium-sparing diuretics like ...
Torasemide. Highly bound (>99%). Torasemide, also known as torsemide, is a diuretic medication used to treat fluid overload due to heart failure, kidney disease, and liver disease. It is a less preferred treatment for high blood pressure. [ 1] It is taken by mouth or by injection into a vein.