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PCBs may play a role in the development of cancers of the immune system because some tests of laboratory animals subjected to very high doses of PCBs have shown effects on the animals' immune system, and some studies of human populations have reported an association between environmental levels of PCBs and immune response.
Ortho-PCBs may alter hormone regulation through disruption of the thyroid hormone transport by binding to transthyretin. [8] Coplanar PCBs are similar to dioxins and furans, both bind to the aryl hydrocarbon receptor (AhR) in organisms and may exert dioxin-like effects, in addition to the effects shared with non-coplanar PCBs.
Polychlorinated biphenyls (PCBs), derived from biphenyl, of which 12 are "dioxin-like". Under certain conditions PCBs may form dibenzofurans through partial oxidation. Polybrominated analogs of the above classes may have similar effects. "Dioxin" can also refer to 1,4-dioxin or p-dioxin, the basic chemical unit of the more complex dioxins. This ...
Nov. 13, 2023: An additional lab, SGS Galson, received samples of the air in Poe Hall. The company reported the results to NC State on Nov. 14. The results did not appear to indicate ...
Exposure to the coplanar stereoisomer 3,3',4,4',5,5'-hexabromobiphenyl (but not the non-coplanar stereoisomer) in genetically susceptible mice is known to cause immunotoxicity and disorders related to the central nervous system, and even at doses as low as 2.5 mg/kg, excess neonatal fatalities are observed (LD 50 is from 5–10 mg/kg). [1]
No harmful levels of carcinogenic PCBs were found inside the missile launch facilities at F.E. Warren Air Force base in Wyoming, the service said Tuesday, as it looks for possible causes for ...
“The existing evidence suggests that this compound can cause liver, developmental, blood and endocrine effects in the human body,” Jamie Alan, an associate professor of pharmacology and ...
Today, concentrations of dioxins are found in all humans, with higher levels commonly found in persons living in more industrialized countries. The most toxic dioxin, 2,3,7,8-tetrachlorodibenzodioxin (TCDD), became well known as a contaminant of Agent Orange , a herbicide used in the Malayan Emergency and the Vietnam War . [ 11 ]