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Splenic sequestration crisis is a life-threatening illness common in pediatric patients with homozygous sickle cell disease and beta thalassemia. Up to 30% of these children may develop splenic sequestration crisis with a mortality rate of up to 15%.
Increased deoxygenation causes sickling of red blood cells, which adhere to the spleen wall and splenic macrophages causing ischemia. [2] This ischemia can result in splenic sequestration, where large amounts of blood pool in the spleen but do not flow within vasculature. [11]
The spleen is especially prone to damage in SCD due to its role as a blood filter. A splenic sequestration crisis, also known as a spleen crisis, is a medical emergency that occurs when sickled red blood cells block the spleen's filter mechanism, causing the spleen to swell and fill with blood. The accumulation of red blood cells in the spleen ...
Treatment of complications. Aplastic crisis. This should be suspected if there is a significant drop in the hemoglobin level ... Splenic and hepatic sequestration
Acquired asplenia occurs for several reasons: . Following splenectomy due to splenic rupture from trauma or because of tumor; After splenectomy with the goal of interfering with splenic function, as a treatment for diseases (e.g. idiopathic thrombocytopenic purpura, thalassemia, spherocytosis), in which the spleen's usual activity exacerbates the disease
Usually, treatment continues until the patient has reached their target height, or they have stopped growing, she explains. However, there are certain cases where GH therapy could be lifelong.
Mounjaro vs. Ozempic: Which Is Better for Weight Loss? This article was reviewed by Craig Primack, MD, FACP, FAAP, FOMA. In one corner, we’ve got Mounjaro, and in the other, Ozempic.
Splenosis is the result of spleen tissue breaking off the main organ and implanting at another site inside the body. This is called heterotopic autotransplantation of the spleen. It most commonly occurs as a result of traumatic splenic rupture or abdominal surgery.