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  2. Apixaban - Wikipedia

    en.wikipedia.org/wiki/Apixaban

    [6] [7] Other side effects may include bleeding around the spine and allergic reactions. [6] Use is not recommended during pregnancy or breastfeeding. [1] [7] Use appears to be relatively safe in those with mild kidney problems. [7] Compared to warfarin it has fewer interactions with other medications. [10] It is a direct factor Xa inhibitor. [6]

  3. Drug expiration - Wikipedia

    en.wikipedia.org/wiki/Drug_expiration

    The labeled expiration date is a manufacturer's promise for a time until which the drug will have full efficacy and be safe as manufactured. [4] The labeled expiration date is not an indication of when a drug has become ineffective or unsafe to use. [4] Many drugs are effective for years after their expiration dates. [4]

  4. Is It Safe to Use Expired Vitamins? The Truth About Vitamin ...

    www.aol.com/vitamins-expire-nutritionists-weigh...

    “There isn’t a promise that the vitamin will pack a full punch if you take it after the expiration date, but there aren’t any notable side effects,” says Davis-Cadogan. How to dispose of ...

  5. Expiration date - Wikipedia

    en.wikipedia.org/wiki/Expiration_date

    [6] The expiration date of pharmaceuticals specifies the date the manufacturer guarantees the full potency and safety of a drug. Most medications continue to be effective and safe for a time after the expiration date. A rare exception is a case of renal tubular acidosis purportedly caused by expired tetracycline. [7]

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  7. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    The key step of this reaction is a (3+2)cycloaddition of a p-methoxyphenylchlorohydrazon derivate and a p-iodophenyl-morpholin-dihydropyridin derivate. After the following elimination of HCl and morpholine, the iodine is substituted by 2-piperidinone by copper-catalization and the ethyl esther is converted to an amide . This reaction was ...

  8. 3 Winter Sleep Problems & How to Fix Them - AOL

    www.aol.com/3-winter-sleep-problems-fix...

    According to American Family Physician, 4% to 6% of people may experience seasonal depression, while as many as 10% to 20% may have a mild case of SAD. The condition is four times more common in ...

  9. Shelf life - Wikipedia

    en.wikipedia.org/wiki/Shelf_life

    High-acid canned foods (tomatoes, fruits) will keep their best quality for 12 to 18 months; low-acid canned foods (meats, vegetables) for 2 to 5 years. [5] "Sell by date" is a less ambiguous term for what is often referred to as an "expiration date". Most food is still edible after the expiration date. [6]

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