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90 Y plays a significant role in the treatment of hepatocellular carcinoma (HCC), leukemia, and lymphoma, although it has the potential to treat a range of tumors. [9] Trans-arterial radioembolization is a procedure performed by interventional radiologists, in which 90 Ymicrospheres are injected into the arteries supplying the tumor. [10]
Radiation therapy is used to kill cancer cells; however, normal cells are also damaged in the process. Currently, therapeutic doses of radiation can be targeted to tumors with great accuracy using linear accelerators in radiation oncology; however, when irradiating using external beam radiotherapy, the beam will always need to travel through healthy tissue, and the normal liver tissue is very ...
These are combined with indium-111, lutetium-177 or yttrium-90 for treatment. [5] 111 In is primarily used for imaging alone, however in addition to its gamma emission there are also Auger electrons emitted, which can have a therapeutic effect in high doses. [6] 90 Y is bound with DOTATOC for PRRT treatments. The natural somatostatin receptor ...
The therapy is administered intravenously through gravity, syringe, or a Peristaltic Infusion Pump. [30] The major warnings include renal toxicity, infertility in males, and embryo/fetal harm. General side effects of this radioligand therapy include fatigue, nausea, dry mouth, anemia, decreased appetite, and constipation.
Modern radiation therapy aims to reduce side effects to a minimum and to help the patient understand and deal with side effects that are unavoidable. The main side effects reported are fatigue and skin irritation, like a mild to moderate sun burn. The fatigue often sets in during the middle of a course of treatment and can last for weeks after ...
After a further waiting time, the radiotherapy (90 Y-DOTA-biotin) is administered. Due to the high affinity of biotin to avidin and streptavidin, the radiotherapy accumulates where the antibody is, namely in the tumour, where it delivers its radioactivity. [3] Example of a 90 Y-DOTA-biotin compound. The structure of the linker, as well as its ...
Naturally occurring strontium is nonradioactive and nontoxic at levels normally found in the environment, but 90 Sr is a radiation hazard. [4] 90 Sr undergoes β − decay with a half-life of 28.79 years and a decay energy of 0.546 MeV distributed to an electron, an antineutrino, and the yttrium isotope 90 Y, which in turn undergoes β − decay with a half-life of 64 hours and a decay energy ...
Yttrium (90 Y) clivatuzumab tetraxetan (trade name hPAM4-Cide) is a humanized monoclonal antibody-drug conjugate designed for the treatment of pancreatic cancer. [1]The antibody part, clivatuzumab (targeted at MUC1), is conjugated with tetraxetan, a chelator for yttrium-90, [2] a radioisotope which destroys the tumour cells.
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