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The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells . DAB1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain and during adult neurogenesis .
The spontaneous autosomal recessive scrambler mutation on chromosome 4 causes a deficiency of DAB1, encoding disabled-1, a protein involved in the signaling of the Reelin protein, lacking in the reeler mutant, [3] Dab1-scm homozygous mutants possess a reeler-like phenotype with respect to cell malpositioning in cerebellar cortex, hippocampus, and neocortex.
5649 19699 Ensembl ENSG00000189056 ENSMUSG00000042453 UniProt P78509 Q60841 RefSeq (mRNA) NM_173054 NM_005045 NM_011261 NM_001310464 RefSeq (protein) NP_005036 NP_774959 NP_001297393 NP_035391 Location (UCSC) Chr 7: 103.47 – 103.99 Mb Chr 5: 22.09 – 22.55 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Reelin, encoded by the RELN gene, is a large secreted extracellular matrix ...
The city Department of Education is so intent on firing a disabled teacher that it went to court two days before Christmas to terminate him. ‘Heartless’ NYC DOE tried to fire disabled special ...
No Iowa Hawkeyes women's basketball player will wear Caitlin Clark's No. 22 again. The number will be retired in a ceremony Feb. 2 at Carver-Hawkeye Arena, the Iowa athletic department announced ...
Kansas City Chiefs quarterback Patrick Mahomes celebrates as he heads off the field following an NFL football game against the Los Angeles Chargers Sunday, Dec. 8, 2024, in Kansas City, Mo.
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain.
UAE’s purchase of our Ports and Taiwan’s acquisition of 3Com. 2 Yes, these acquisitions cause alarm and raise significant and credible concerns, however, if our system is capitalism and our mission is the free flow of capital then our intrusions help materialize fears of our friends losing trust in our system. This will only give credence ...