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The hazard ratio is the effect on this hazard rate of a difference, such as group membership (for example, treatment or control, male or female), as estimated by regression models that treat the logarithm of the HR as a function of a baseline hazard () and a linear combination of explanatory variables:
If the hazard ratio is , there are total subjects, is the probability a subject in either group will eventually have an event (so that is the expected number of events at the time of the analysis), and the proportion of subjects randomized to each group is 50%, then the logrank statistic is approximately normal with mean () and variance 1. [4]
Relative risk (risk ratio) RR EER / CER: 1.25 Relative risk increase RRI (EER − CER) / CER, or RR − 1 0.25, or 25% Attributable fraction among the exposed: AF e
The hazard ratio is the quantity (), which is = in the above example. From the last calculation above, an interpretation of this is as the ratio of hazards between two "subjects" that have their variables differ by one unit: if P i = P j + 1 {\displaystyle P_{i}=P_{j}+1} , then exp ( β 1 ( P i − P j ) = exp ( β 1 ( 1 ...
A hazard quotient is the ratio of the potential exposure to a substance and the level at which no adverse effects are expected. If the Hazard Quotient is calculated to be less than 1, then no adverse health effects are expected as a result of exposure. If the Hazard Quotient is greater than 1, then adverse health effects are possible.
A concept closely-related but different [2] to instantaneous failure rate () is the hazard rate (or hazard function), (). In the many-system case, this is defined as the proportional failure rate of the systems still functioning at time t {\displaystyle t} (as opposed to f ( t ) {\displaystyle f(t)} , which is the expressed as a proportion of ...
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In practice the odds ratio is commonly used for case-control studies, as the relative risk cannot be estimated. [1] In fact, the odds ratio has much more common use in statistics, since logistic regression, often associated with clinical trials, works with the log of the odds ratio, not relative risk. Because the (natural log of the) odds of a ...